Immunity is a being's resilience or total impervious nature to supernatural powers, objects, effects, or forces that affect other members of its species. It appears that a creature's age, power level, and/or rank within its species hierarchy dictates if it is immune to its species' weaknesses and to what degree it is immune.
Characters with Immunity
Angelic Beings
- Archangels - Lucifer is completely immune to Hex Bags, Metatron's spell, Enochian Brass Knuckles, Angel-killing bullets, Supernatural Handcuffs, and Angel blades. He is highly resistant and even immune to almost all angel wardings and has limited immunity to Holy Fire, as it can easily destroy regular angels, it could only banish him for a few minutes, but cause him no harm at all. Holy fire could trap regular angels permanently and literally forever, but could only hold Lucifer for a few minutes, even if it is empowered by an angel trap and angel suppressing sigil, he could still disable and remove it in minutes. He has nearly complete immunity to The Colt, he is one of the five beings in all of existence that the Colt cannot kill. He was immune to death while Death was bound to him. Michael, Raphael and Gabriel also have some degree of immunity to these angelic weaknesses. Gabriel was able to easily destroy the powerful angel wardings and angel blocking sigils that kept the Seraph Castiel from entering a certain large area. After being engulfed in holy fire (something that can instantly destroy all regular angels), Michael was only banished for a few minutes, and returned without even a scratch or burn on him. He also was highly resistant to the enhanced Supernatural Handcuffs, able to retain superhuman strength, enough to effortlessly overpower Castiel, lift him off of his feet and slam him with great force, and restrain him with ease, making the entire Men of Letters bunker violently quake and was able to effortlessly create a 12-hour rift to Purgatory with just a snap of his fingers.
- Angels
- Castiel (formerly) - While imbued with the power of the 30-40 million souls of Purgatory, he became completely immune to angel blades and angel wards.
- Nephilim
- Jack is completely immune to angel blades, angel banishing sigils and angel wards despite possessing angelic heritage. He was also immune to the Ma'lak Box, a coffin designed to keep any creature locked inside, even a being as tremendously powerful as an Archangel. However Jack can be weakened by very heavy angel warding.
Demons
- White-eyed Demons as the most powerful and durable demons ever to exist, are immune to hallowed ground and at least highly resistant, but not even immune to holy water. Both Lilith as well as Alastair fall into this category.
- Alastair was completely immune to hallowed ground, the smiting power of average angels, and iron. He had limited immunity to the demon-killing knife[1], Salt and Holy water. Even after Sam Winchester proved capable of exorcising a powerful multicolor-eyed demon with his mind, he could only tickle Alastair in the beginning of Season 4. (Alastair went on to lose that resistance as Sam built his powers.) So far, he's the only demon proven to be immune to smiting by angels at all.
- Lilith is immune to hallowed ground and possibly to holy water. She was at first completely immune to Sam's powers, even when they proved capable of eliminating Alastair, but later lost this immunity when Sam got stronger by binging on demon blood. She's also displayed partial immunity to the devil's trap, in that she retains some of her abilities, such as telekinesis and terrakinesis; she was able to use them to quickly expel a devil's trap bullet that was inserted into her vessel's body. It can be assumed that she is immune to an angel smiting, since this is the case of Alastair, a fellow white-eyed demon who is inferior to Lilith in both rank and strength.
- The Princes of Hell, as the oldest of the old demons after Lilith, possessed much stronger durability than the other regular demons.
- Azazel was immune to holy water and hallowed ground.
- Ramiel was fully immune to angel blades and the demon-killing blade.[2] He is also the only demon to display complete immunity to devil's traps.
- The only known multicolor-eyed demon Samhain was completely immune to iron. He resisted Sam's psychic exorcism better than other demons Sam had faced until then, but he was ultimately overcome by it.
- Knights of Hell, as one of the first fallen, first born demons, cannot be killed with the ancient demon-killing knives of the Kurds, but at least some of them are not entirely immune to it. The Knights of Hell are supposed to have only one fatal vulnerability, the First Blade when wielded by someone bearing the Mark of Cain.
- Cain was completely immune to the demon-killing knife[3] and the angelic white light. As a Knight of Hell with the Mark, he has only one fatal weakness, the First Blade wielded by someone bearing the Mark of Cain, so it can be presumed that Cain was also immune to angel blades and angelic smiting. He also displayed partial immunity to the devil's trap as he stated the trap couldn't hold him for a long time and that he retained a part of his super strength and his telekinesis.
- Dean - As a Knight of Hell, Dean was supposed to be immortal and immune to most forms of harm, except for the First Blade when wielded by someone bearing the Mark of Cain. He also displayed partial immunity to holy water.
- Abaddon was completely immune to exorcism rites and hallowed ground. The demon-killing knife[4] caused her acute pain, and holy fire could destroy her vessel, but neither could kill her. She also displayed partial immunity to holy water.
- Crossroad Demons
- Crowley was immune to hallowed ground; he had some resistance to holy water and great resistance to Rowena's demon-killing spell.
- Black-eyed Demons as the most commonly and weakest kind of demons, they can easy be killed by the demon-killing knife, angel blades, the colt.
- Meg was immune to hallowed ground.
- Ruby was immune to hallowed ground.
- Casey had some immunity to the devil's trap; she became paralyzed when inside one, but she could still cause brief earthquakes and some weather phenomena.
Humans
- Sam Winchester - He is completely immune to Croatoan Virus and demonic photokinesis. Sam is initially susceptible to Lilith's powers, but drinking demon blood he gained complete immunity. During his soulless stint, Sam was completely immune to the truth spell of Veritas. While Death was bound to him, Sam was temporarily immune to and incapable of dying.
- Dean Winchester - He is completely immune to being made a Rabid due to the influence of the Darkness. While imbued with the power of the Mark of Cain, he became completely immune to Gaelic Obliteration Spell. Dean is initially susceptible to Abaddon's powers, but holding The First Blade he gained completely immunity. While Death was bound to him, Dean was temporarily immune to and incapable of dying.
- Bobby Singer - While Death was bound to him, Bobby was temporarily immune to and incapable of dying.
- Lily Sunder - Lily has displayed an immunity to angelic abilities.
Ghosts
- Jacob Karns - He is completely immune to hallowed ground and has limited immunity to salt.
- Thomas Gregory - He is immune to hallowed ground.
- Isabella - She has Immunity to hallowed ground.
- Hugo Moriarty - He has limited immunity to iron.
Beings from Purgatory
- Leviathans and Eve - Leviathans and Eve are immune to angelic powers, since they can block them.
- Dick Roman - He has limited immunity to Borax.
- Edgar - He has limited immunity to Borax.
Monsters
- Alpha Shapeshifter - He is completely immune to silver.
- Alpha Vampire - He has some degree of immunity to dead man's blood.
Zombies
Notes