Indestructibility is the property to be beyond destruction, no matter how powerful an attempt to destroy this object or entity is.

Characters with this ability

All characters are listed in alphabetical order.

Nigh Indestructibility

These supernatural entities or objects that are nearly completely indestructible, next to completely unkillable and can only be killed or destroyed by beings of the same level of power or higher.

• Cain - As the bearer of the Mark of Cain and the very first Knight of Hell, he can't be killed by any earthly weapons or conventional means. Only with the First Blade by another wielder of the Mark of Cain could he be killed, making him practically indestructible, and virtually impossible to truly kill.
• Death - Death had immunity against nearly all physical and supernatural attacks. He is nearly completely indestructible. He could only be killed by his own scythe.
• Famine, Pestilence, and War - Their physical embodiments can be harmed by earthly objects and destroyed by Death's Scythe, but their attributes can never be destroyed.
• God - God is nearly completely invincible and indestructible; only the Darkness could kill him.
• Lucifer (formerly) - As an Archangel, Lucifer was already virtually indestructible, next to invincible and almost impossible to kill. As the former bearer of the Mark of Cain, Lucifer was nearly completely invincible and indestructible and absolutely impossible to kill, and not even the archangel blade even if wielded and used by an archangel could kill him.
• The First Blade - The First Blade can't be destroyed by any known means. Though, Abbadon announced that she had plans to destroy it. 
• Book of the Damned - Indestructible due to a spell.
• The Darkness - After a combined attack from angels, demons, and witches, Amara was still alive, though barely standing. Not only that, even after being struck by Lucifer following the combined attack, she was still had enough strength to not only still manage to easily overpower both Lucifer and God, but also mortally wound the latter. Her only possible weakness is light equivalent to 10,000 suns going supernova at once or the Soul Bomb and even then the person carrying the bomb must stand close enough to her before setting it off.
• The Shadow - The Shadow survived a metaphysical supernova blast that could destroy God and the Darkness.
• Yokoth - Stated to be impossible to kill her even after nearly a hundred years of trying.
• Deities (formerly) - As described by Sam, deities were once next to invincible when they still had their millions of worshipers and religions, however they lost their power from lack of worship and became much more vulnerable. They still are close to indestructible.
• Jack - As The new God and absorbing the primordial entity's powers and the Darkness, Jack is completely indestructible and invincible.
• Knights of Hell - Knights of Hell were created by Cain with the First Blade, making them virtually indestructible.

Advanced Indestructibility

These beings are among the most resilient and powerful in the Supernatural universe, they have very few weaknesses and are virtually indestructible and could only be killed by nigh-omnipotent forces or very rare, extremely powerful supernatural weapons.

• Archangels - The Darkness, God, original Death and Jack are the only beings in existence that can harm and kill them without much effort. When it comes to weapons, only an Archangel Blade (provided it is wielded by an Archangel) has been confirmed to be able to kill them. It has been shown that the spear owned by the Alternate Kaia Nieves can harm Archangels as evidenced with Michael, though whether it can kill them is not yet known. Archangels are nearly completely indestructible, next to invincible and virtually impossible to harm or kill. Asmodeus even stated that an Archangel blade (provided it is wielded and used by another archangel) is the only known weapon in existence capable of killing an Archangel.
• Eve - Eve existed in Purgatory for a very long time, and was related to Leviathans. Only one substance was said to be able to kill her. She is otherwise indestructible.
• Jack - In Jack in the Box, Sam and Dean both state that Jack can't be killed, however he can be briefly contained.
• Leviathans - Indestructible beasts created by God, one of them survived having a car dropped on it. They are nearly impossible to kill or even harm. They also can't be harmed or killed by point-blank gunshots, shotgun blasts, heavy, rapid gunfire, extremely powerful acids, very lethal poisons, electrocution, bombs, explosions, decapitation, dismemberment, or extreme physical force such as their whole bodies being crushed into pieces or having a car dropped on them from 20 feet. Only the Bone of Righteous Mortal Washed in the Three Bloods of Fallen is confirmed to be able to kill them.

Medium Indestructibility

These Supernatural beings have certain vulnerabilities, and could also be killed by some higher beings like archangels.

• Angels - Angels can't be harmed but by a few weapons and beings. Their vessels, while occupied, are nearly indestructible, as long as the means by which the vessel is harmed doesn't affect the angel.
• Deities - According to Sam, while they were still worshiped, they were next to invincible. Despite having lost most of their worshipers, however, they are still almost indestructible.
• Fairies - Fairies are immune to several forms of harm.
• Jane - As the offspring between an angel and a human, she is very resilient to physical damage.
• Princes of Hell - They are nearly indestructible, and Immune to most weapons that can easily harm and kill demons, although can be easily killed by higher beings and weapons such as The Colt and Archangels.
• The Wicked Witch - She was almost impossible to destroy, as even things that killed regular witches had no effect on her, such as decapitation, gunshot to the head or setting her on fire.
• White-eyed Demons - They were highly resistant to salt and holy water. They couldn't be killed by Ruby's Knife as well as a regular angel's smiting.
• Whore of Babylon - The Whore was invulnerable to almost every known form of physical harm.

Low Indestructibility

These Supernatural beings have certain non-physical vulnerabilities, but they could also be killed by a lot of higher-tier entities like angels or extremely powerful demons.

• Alphas - Alphas are immune to everything their children are immune to, and are more resilient to their weaknesses as well. Some Alphas are immune to weaknesses their children share.
• Black-eyed and Red-eyed demons - Despite being at the low end of the demonic hierarchy, as demons, they are very difficult to harm or kill. Most harm to their vessel is irrelevant, as a demon can survive even if their vessel is damaged beyond its ability to stay alive. They cant be killed by decapitation, dismemberment, gunshots, stab wounds, or extreme physical force.
• Dragons - Dragons can shrug off almost any physical attack and they are almost indestructible.
• Hellhounds - Although they can be hurt by firearms and common demonic weaknesses, Hellhounds are extremely resilient to damage, even that inflicted by their own kind.
• Jefferson Starships - As hybrids, they share the strengths (and immunities) of their "pure" counterparts.
• Nachzehrer - Nachzehrer are "already dead", so decapitation and other forms of physical attack can't destroy them.
• Phoenix - A Phoenix can't be killed by hanging, gunfire, stab wounds, or other forms of physical attack.
• Siren - Sirens are very resilient to most known forms of destruction.
• Vampires - Vampires are immune to almost all physical harm, including stakes, knives and bullets.
• Arachne - Arachne are impervious to bullets, knives and fire. They can even regrow lost limbs (except for their heads) Only can be killed by decapitation.

Minimal Indestructibility

These supernatural beings, though slightly harder to kill than humans, have many vulnerabilities, and can often be killed by conventional means like fire, beheading, silver knives, and higher-tier entities.

• Amazons - Despite their strength and other abilities, Amazons are as vulnerable as any human.
• Changelings - Changelings are highly resistant to damage.
• Djinn - Djinn are resilient to bullets.
• Ghouls - Ghouls can shrug off most physical attacks.
• Kitsune - Kitsune can't be destroyed by physical attacks.
• Okami - Okami can't be killed by conventional weapons.
• Pishtaco - They are invulnerable to most physical attacks.
• Rawhead - Invulnerable to physical attacks.
• Shtriga - Shtriga are invulnerable to all forms of weaponry unless they're feeding.
• Skinwalkers - They possess most of the invulnerabilities of werewolves, which include gunfire, knives, and most other types of physical attacks.
• Wendigo - Wendigo can't be harmed by physical attacks. Guns and knives are completely useless against them.
• Werewolf - Werewolves can shrug off almost any physical attack.
• Witch - Despite their supernatural abilities, witches, like Amazons, are as vulnerable as humans.
• Wraith - Wraiths cannot be destroyed by most weapons.

Unknown Indestructibility

• Cambions/Katakos - It is unknown how you can actually injure, trap, mislead and/or kill a Cambion. It is also not known whether cambions can live forever or whether they can die of an aging process. However, Castiel has hinted that the Demon-Killing Knife can kill him.

Trivia

• In Appointment In Samarra, Death claimed that the soul can be damaged but not broken, not even by him, despite the fact that he was nearly equal in power to God, who created souls. Many fans took that as him meaning that souls are essentially indestructible. However, in the same conversation, Death also called the soul vulnerable and impermanent, suggesting the opposite. Moreover, it was later revealed that souls can in fact be split in two through powerful magic.
  • It is more likely that Death meant that the soul can't be broken into pieces without repercussions, as the soul splitting spell had the effect of actually seperating the person into versions of themselves, each one only retaining one of two opposite aspects of the original person (good/bad etc.).